NEFL and Stroke: Plasma NfL quantified within the first 24 h of stroke has been proposed as a biomarker of stroke outcomes.39 However, a systematic review of the temporal trajectory of NfL in stroke determined that the levels of this biomarker significantly increased in the early subacute period after stroke, that is between 14 and 21 days after injury, when compared to the acute setting.40 Thus, assessment of time points beyond 48 h after MRgHIFU could potentially reveal a more consistent elevation of this marker.