Microscopy observations of murine melanoma IFN-γ-stimulated B16F10-K1 cells infected with Nc-1-scFv-Fc (Figure 6D, upper panel) or Nc-1 (used as negative control) (Figure 6D, lower panel) showed scFv-Fc binding to both infected and adjacent uninfected cells. The gene discussed is COL18A1; the disease is melanoma.