IL-1β, IL-6, TNF-α, and CGRP were significantly higher in the migraine group than the control group (p < 0.05).CGRP levels were strongly correlated with IL-6 levels.There was no significant difference in IL-2 or IL-10 levels.Unfortunately, there was no analysis for differences between those with chronic and episodic migraine. The gene discussed is TNF; the disease is migraine disorder.