A recent systematic review and meta-analysis found that patients with migraine have significantly higher peripherally circulating interleukin (IL)-6, tumour necrosis factor (TNF)-α, and IL-8 levels than healthy controls, and patients with tension-type headache had higher TNF-α and transforming growth factor (TGF)-β than controls (2). The gene discussed is TNF; the disease is Tension-type headache.