These cells produce and secret many pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), and are the major initial infiltrating immune cells to CNS in sepsis [12]; activation of infiltrating mononuclear phagocytes and resident microglia in the brain is strongly associated with excessive neuroinflammation [13,14]. The gene discussed is IL1B; the disease is Sepsis.