In this contribution, we demonstrate a multimodal cancer treatment platform, reconfigurable DS-ARGN cluster bomb, where gold nanorods are bundled together with RCA-p adhesive tape and densely loaded with Dox and siRNA of PLK1 gene (siRNA-Plk1) to simultaneously execute photothermal therapy, gene therapy and chemotherapy for achieving synergistic precision treatment effects. The gene discussed is PLK1; the disease is cancer.