Our findings unequivocally demonstrate the microbiota (B. pseudolongum)‐metabolite (PA)‐ FFAR3 axis, which underlies the cognitive benefits of TRF, and highlight the translational potentials of nondrug intervention strategy, including TRF and other gut microbiota‐derived nutritional intervention, for halting AD progression. Here, FFAR3 is linked to Alzheimer disease.