TRF intervention successfully reduced the positive area of plaques and increased the clustering of microglia in AD mice (Figure 1G,H and Figure S1I,J), accompanied by a reduction in mRNA expressions of tumor necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) (Figure 1I,J). The gene discussed is TNF; the disease is Alzheimer disease.