CACNA1B and Alzheimer disease: A clear discrimination between AD group and AD+TRF group was achieved (Figure 2B) and the core contributors identified by PLSDA for separation included calcium voltage‐gated channel subunit alpha1 B (Cacna1b), protein kinase C zeta (Prkcz), and Cyclooxygenase‐2 (COX2), which were differentially expressed between the two groups as assessed by univariate analysis (Figure 2C).