INS and fatty liver disease: In line with this, bioinformatic analysis comparing liver proteome profiles of mice switched to KD with those remaining on WD revealed that KD influenced different molecular pathways stimulating 77 proteins involved in lipid metabolism (Z score ≥2) while lowering (Z score ≤2), respectively, 32 proteins concerning insulin resistance, 114 proteins related to glucose metabolism, and 44 proteins associated with hepatic steatosis (Figure 2D, Supplementary Table 1).