Gal-3 plays a fundamental role in driving MASH-associated liver fibrosis (28) being produced by a subset of liver infiltrating monocyte-derived macrophages (MoMFs) characterized by the co-expression of the triggering receptor expressed on myeloid cells 2 (TREM2) and CD9 as well as by the production of other pro-fibrogenic mediators such as osteopontin (OPN) (29). Here, SPP1 is linked to Hepatic fibrosis.