In addition, the expression of CD62L and Ly108 in the CD44+PD-1+CD8+ TILs, and the proportion of Ly108+ Tpex cells, especially CD62L+CD8+ Tpex cells, significantly increased in the mouse B16 hormonal tumor model compared with the PBS control group (Supplementary Figures S5A, B). Here, CD8A is linked to neoplasm.