CD8+ TTSM cells in tumor-draining lymph nodes (TdLNs) can differentiate into CD8+ Tpex cells [tumor-draining lymph node (TdLN)-CD8+ Tpex] and gradually migrate to the tumor microenvironment where they become TME-CD8+ Tpex cells, further differentiating into transitory effector-like exhausted T cells (Texint) cells that sustain antitumor effects (6). This evidence concerns the gene CD8A and neoplasm.