One such example is the single-nucleotide polymorphism (SNP) kinesin family member 5A(KIF5A)- phosphatidylinositol 5-phosphate 4-kinase type 2 gamma (PIP4K2C)/rs1678542, which has been found to be associated with significant genetic susceptibility in the Pakistani RA population. The gene discussed is KIF5A; the disease is rheumatoid arthritis.