IL4 and Alzheimer disease: Excessive IL-33 has been demonstrated to cause AD-like inflammation in hK14mIL-33tg mice (transgenic mice for overexpress IL-33 in their skin) by producing large amounts of T2 cytokines, such as IL-4, IL-5,and IL-13, with increasing and activating ILC2s in the skin, lymph nodes, and peripheral blood (157).