GSDME was observed to be highly expressed in the renal tubules of SLE patients and pristane-induced lupus mice, while Caspase-3/GSDME-mediated pyroptosis, autoantibody, glomerular IgG deposition and renal lesions were ameliorated in Gsdme-/- lupus mice (119). Here, CASP3 is linked to systemic lupus erythematosus.