For example, previous studies from our group indicate that in combination with anti-PD1 and ficerafusp alfa (BCA101), an anti-EGFR with a TGF-β trapping arm was able to significantly reduce the growth of tumors produced by B16-hEGFR (B16 cells engineered to overexpress human EGFR) (311), an otherwise cold syngeneic tumor model. The gene discussed is PDCD1; the disease is neoplasm.