Innate cells dampen T-cell activity through several methods that include, T-cell suppression (by induction of Treg differentiation through TGF-β and IL-10), physical exclusion of tumor infiltrating lymphocytes (TILs) from the tumor core by TAMs/M2 macrophages (134), inhibition of T-cell proliferation and activation by limiting metabolites (135), and finally T-cell exhaustion. This evidence concerns the gene TGFB1 and neoplasm.