CD8A and familial pancreatic carcinoma: A case study report of a metastatic pancreatic cancer patient revealed that a combination of chemotherapy (oxaliplatin) with immunotherapy and fractional radiation treatment was able to change the features of the TME to a “hot tumor” phenotype via several methods including activation of cGAS-STING, increased CXCL9 and CXCL10 leading to improved CD8+T-cell infiltration and also by inhibiting DNA damage repair (308).