Several CAR-T cell therapies targeting antigens such as EGFR (NCT03152435, NCT03542799), NKG2D and NKG2D ligands (NCT03370198, NCT03310008, NCT03692429), CEA (NCT02959151, NCT03682744, NCT02850836), c-Met (NCT03638206), and EpCAM (NCT03013712) have been investigated in patients with metastatic colorectal cancer. Here, KLRK1 is linked to metastatic colorectal cancer.