IL2 and rheumatoid arthritis: Among them, the fragment of annexin A11387-401 (SRAHLVAVFNEYQRM) induced a statistically significant difference in IFN-γ (p = 0.0299) and IL-2 (p = 0.0186) production between HLA-DRB1∗01:01-positive RA patients and healthy donors (Fig. 1N, O).