Besides, the LC-MS/MS analysis identified several peptides not selected by phage display, but overlapped with previously validated RA-relevant HLA-II epitopes, for example, with vimentin66–78 (SAVRLRSSVPGVR),4 histone H2B63-74 (MNSFVNDIFERI), and histone H428-40 (DNIQGITKPAIRR),5 which elicited CD4+ T cell response in RA patients. The gene discussed is CD4; the disease is rheumatoid arthritis.