Epilepsy caused by mutation of the SCN2A gene manifests as benign neonatal/infant epilepsy with a good prognosis but can also manifest as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy of infancy with migrating focal seizures, Lennox–Gastaut syndrome, genetic epilepsy with febrile seizures plus and other severe epileptic encephalopathies that cannot be classified (13, 14). Here, SCN2A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.