Enhancer of zeste homolog 2 (EZH2) is responsible for the trimethylation of lysine 27 on histone H3 (H3K27me3), serving an essential role in a Polycomb Repressive Complex 2 (PRC2)-dependent manner, which represses expression of multiple tumor suppressive genes through the H3K27me3 mediated by EZH2 (67). Here, EZH2 is linked to neoplasm.