CHRDL1 and SLIT3 downregulation contributes to the invasive behavior and progression of colorectal cancer cells and thyroid malignancies (66, 67), and decreased DNASE1L3 expression may be a novel diagnostic and prognostic biomarker associated with immune infiltrates in LUAD (68); these results are consistent with our findings. This evidence concerns the gene CHRDL1 and colorectal cancer.