ENO1 and cancer: Because glycolysis is a crucial metabolic process, providing energy to cancer cells, we examined the correlation between EFTUD2 and key enzymes involved in glycolysis in LUAD by using TIMER and identified significant associations between EFTUD2 and various regulatory enzymes including ENO1, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), GPI, HK2, LDHA, PFKM, pyruvate kinase M2 (PKM2), PGAM1, PGK1, TPI1, and aldolase B (ALDOB; Figure 6B).