Notably, three upregulated metabolites in the NF-PitNET group—6,7-Dihydroxycoumarin, o-Cresol, and Hypoxanthine—were positively correlated with indicators of disease severity, with 6,7-Dihydroxycoumarin and o-Cresol showing positive correlations with tumor Ki-67 expression, and Hypoxanthine correlating positively with tumor Knosp grade and aggression (Figures 6A,C). The gene discussed is MKI67; the disease is neoplasm.