Thus, the CYP2E1 inhibitor fomepizole is unlikely to mitigate the analgesic effects of AAP, and high-dose AAP with fomepizole rescue may be a potent analgesic cocktail that spares the toxicities of narcotics, such as constipation, respiratory depression and ultimately dependance. The gene discussed is CYP2E1; the disease is Respiratory insufficiency due to muscle weakness.