Additionally, pathways associated with neurodevelopment and synaptic function (e.g., autism signaling, CREB signaling in neurons, netrin signaling), inflammation and immune regulation (e.g., phagosome formation, estrogen receptor signaling), and G-protein-coupled receptor and signal transduction (e.g., G-protein coupled receptor signaling, G alpha (q) signaling, S100 family signaling, RHO GTPase cycle) were significantly enriched. The gene discussed is RHO; the disease is autism.