RTH: thyroid hormone resistance; TSH: thyroid-stimulating hormone; T3: triiodothyronine; T4: thyroxine; PTC: papillary thyroid carcinoma; mPTC: papillary thyroid microcarcinoma; RAI: radioactive iodine ablation; TMNG: toxic multinodular goiter; THB: thyroid hormone receptor-beta; FTC: follicular thyroid carcinoma. The gene discussed is THRB; the disease is toxic multinodular goitre.