CRTC1 and steatosis: Inhibition of TORC1 through overexpressing TSC1,2, or overexpressing Proline-rich Akt substrate 40 kDa (PRAS40), or by feeding flies with rapamycin, all induced steatosis in oenocytes (Figure 2E and S2B–C), as observed following Hnf4 knockdown in oenocytes (Figure 1N).