EGFR and neoplasm: Pre-mixing and pre-targeting with EGFR-PEG BsAbs significantly increased mRNA-LNP delivery to the tumor tissue (over 8- and 7-fold) while reducing the radiance in the liver by a third and half compared to untargeted LNPs, respectively, 8 h after luciferase mRNA-LNP administration (Figures 3B and S2D).