The singlet oxygen (1O2) generated by LCL/ZnO activates signaling pathways in tumor-derived endothelial cells, including transient receptor potential vanilloid-4 (TRPV4) and endothelial nitric oxide synthase (eNOS), which contribute to vascular normalization (Zhang et al., 2022a). The gene discussed is NOS3; the disease is neoplasm.