MDH2 and frontotemporal dementia: Although FTD still showed higher MDH (75.6 ± 11.0) and CS (10.9 ± 1.7) activity levels than RBD (MDH: 34.7 ± 5.9, CS: 7.2 ± 1.2), at CTmax the difference over JD seen at baseline was lost, due to a JD-specific 72% increase in MDH (71.0 ± 12.0) and 47% increase in CS (10.4 ± 2.2) activity at CTmax, as seen in cytosolic enzymes (Supplementary Table S7).