Another large meta-analysis of 4982 women with GDM who were treated with glyburide and 4191 treated with insulin, newborns of women treated with glyburide were at increased risk for neonatal intensive care unit (NICU) admission (risk ratio, RR=1.4), respiratory distress (RR=1.6), hypoglycemia (RR=1.4), birth injury (RR=1.4) and LGA (RR=1.4), compared with those treated with insulin (182). This evidence concerns the gene INS and gestational diabetes.