The results revealed that only TRDMT1 exhibited a protective effect, whereas the remaining 12 genes (NEK2, SMCA, ALYREF, BLM, DNMT1, DNMT3B, TOP2A, TRMT61A, HMMR, EXO1, HNRNPA2B1, INCENP) were identified as risk factors for the recurrence of PCa. Here, TOP2A is linked to posterior cortical atrophy.