The results revealed that only TRDMT1 exhibited a protective effect, whereas the remaining 12 genes (NEK2, SMCA, ALYREF, BLM, DNMT1, DNMT3B, TOP2A, TRMT61A, HMMR, EXO1, HNRNPA2B1, INCENP) were identified as risk factors for the recurrence of PCa. This evidence concerns the gene NEK2 and posterior cortical atrophy.