Furthermore, TMP has been shown to alleviate lung inflammation in an ovalbumin-induced asthma mouse model by downregulating C-C Motif Chemokine Receptor 1 (CCR1), STAT3, and p38 MAPK proteins, thereby inhibiting airway hyperresponsiveness and the release of inflammatory and chemotactic factors (Wei et al., 2016). The gene discussed is CCR1; the disease is asthma.