In a mouse model of induced intracerebral hemorrhage, ligustilide and senkyunolide H were shown to exert potent neuroprotective effects against hemorrhagic stroke by inhibiting the Paired Related Homeobox 1 (Prx1)/Toll-like receptor 4 (TLR4)/NF-κB pathway, and subsequent immune and neuroinflammatory damage (Han et al., 2018). The gene discussed is TLR4; the disease is intracerebral hemorrhage.