Angelman syndrome (AS) is a rare (1:20,000 (Clayton-Smith & Pembrey, 1992)) neurogenetic syndrome caused by the loss of the maternal ubiquitin-protein ligase E3A (UBE3A) gene in the 15th chromosome (Kishino et al., 1997; Matsuura et al., 1997). The gene discussed is UBE3A; the disease is Angelman syndrome.