Using a relatively large prospective cohort of BRCA carriers, Kuchenbaecker and colleagues estimated the cumulative BC risk for individuals aged 80 years to be 72% for BRCA1 and 69% for BRCA2, while the cumulative OC risk was 44% for BRCA1 and 17% for BRCA2 [4]. This evidence concerns the gene BRCA1 and breast cancer.