Considering that (1) childhood obesity is related to the anticipation of puberty, which is also observed in HFD administration animal models; (2) the astrocytes are dynamic cells that respond to changes in the CNS environment, such as obesity; and (3) the astrocytes have a great contribution to the maintenance of the excitability of GnRH neurons, the hypothesis of the present work is that the high‐fat diet (HFD) triggers changes in the activity and morphology of astrocytes that are linked to the anticipation of puberty. Here, GNRH1 is linked to obesity due to melanocortin 4 receptor deficiency.