HP and Alzheimer disease: Principal component analysis (PCA) and partial least squares discrimination analysis (PLS‐DA) showed that the metabolic profiles in Ccx, Hp, corpus callosum (Cc), thalamus (Th) and hypothalamus (Hth) of PRE‐treated mice were remarkably distinguished from AD, indicating that notable spatial metabolic disturbances could be changed by PRE (Figures 1A and S4).