TARDBP and frontotemporal dementia: These animals recapitulate some of the key clinical and neuropathologic features of FTD-GRN in an age-dependent manner, including cognitive deficits (learning and memory), impaired social interactions, neuronal loss, microgliosis, astrogliosis, and TDP-43 proteinopathy [8, 10, 16, 35, 130, 131, 133, 134, 199–201].