To verify whether LINC02167 promotes CRC metastasis through the regulation of the ERK/MAPK pathway, we used the ERK/MAPK pathway activator EGF to enhance the activity of the ERK/MAPK pathway in LINC02167 knockdown CRC cells and the ERK/MAPK pathway inhibitor PD98059 to reduce the activity of the ERK/MAPK pathway in LINC02167 overexpressing CRC cells. The gene discussed is EGF; the disease is colorectal carcinoma.