Silent Information Regulator- 1 or Sirtuin- 1 (SIRT- 1) modulates mitochondrial function, glucose, and lipid metabolism through peroxisome proliferator-activated receptor-gamma (PPAR-γ), mitochondrial transcription Factor A (TFAM), and nuclear respiratory factor activation, which are linked to insulin resistance [58]. This evidence concerns the gene PPARG and Insulin resistance.