To address these knowledge gaps, this study aimed to assess the associations, dose–response relationships and predictive performances of a panel of different systemic inflammation biomarkers (neutrophil count, monocyte count, lymphocyte count, CRP, LMR, NLR, PLR, SII) with incident CVD and CVD subtypes (ischaemic heart disease (IHD), stroke, and heart failure) using UK Biobank data. This evidence concerns the gene CRP and Stroke.