To address these knowledge gaps, this study aimed to assess the associations, dose–response relationships and predictive performances of a panel of different systemic inflammation biomarkers (neutrophil count, monocyte count, lymphocyte count, CRP, LMR, NLR, PLR, SII) with incident CVD and CVD subtypes (ischaemic heart disease (IHD), stroke, and heart failure) using UK Biobank data. The gene discussed is CRP; the disease is stroke disorder.