Certainly, we have also observed that the qRT-PCR results corresponding to the HCA time were inconsistent with the HCA, particularly manifested conspicuously in genes such as FGF7, ANGPT- 1, CXCL12, and IL- 17 A. Apart from the potential molecular mechanisms we previously mentioned, the inhibitory feedback of autocrine signaling could also be one of the causes for this (Nguyen et al. 2017). The gene discussed is CXCL12; the disease is hepatocellular adenoma.