KLF5 and cancer: For example, SE amplifications increase the expression of oncogenes including MYC, SOX2, USP12, KLF5, ZFP36L2, thereby promoting the progression of various cancers, including endometrioma and gastrointestinal tumors (Liu et al, 2021; Xing et al, 2019; Zhang et al, 2018; Zhang et al, 2016).