SPINT1 and B-cell chronic lymphocytic leukemia: Among the significantly upregulated genes in the HR cohort, we identified TOX (p = 0.0110), a transcription factor described to regulate T-cell differentiation and to prevent T-cell overstimulation [44], PAK6 (p = 0.0392), a transcriptional regulator promoting cell survival with overexpression in various tumors [45], and SPINT1 (p = 0.0141, all Student’s t test), a protease inhibitor and negative prognostic marker for treatment response in chronic lymphocytic leukemia [46] (Fig. 5B).