Unlike the membrane-bound CD95L (mCD95L), sCD95L fails to trigger cell death but induces non-apoptotic and pro-inflammatory signaling pathways, which might contribute to the severity of auto-immune and inflammatory disorders including systemic lupus erythematosus (SLE), or Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) (discussed below) and cancers [89]. Here, FASLG is linked to systemic lupus erythematosus.