From a pathologic standpoint, it will be crucial to exhaustively identify the MMPs and ADAMs responsible for CD95L cleavage in order to assess whether the lack of some of them will engender immunosuppression via the accumulation of “precocious differentiation”, while their up-regulation will contribute to the CD95-dependent inflammation contributing to the disease severity in lupus, Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Here, FASLG is linked to systemic lupus erythematosus.