However, the CRISPR-Cas9 analysis of CL-A cell lines uncovered a significant dependence on ZNF181, also showing a high influence score in CL-A samples, and of CENPU, encoding for the centromere-associated protein U, whose role has never been described in GBM so far (Fig. 4C and Supplementary Data 6). The gene discussed is CENPU; the disease is glioblastoma.