The CL-B co-regulated subnetwork included PRAME, PPARG, SALL1, and STAT6. CRISPR-Cas9 analysis confirmed that the main regulators of CL-B cell lines are PITX1, HES4, and SOX10. Notably, the CL-B tumor subclass displays high levels of activity for the TF PPARG, a master metabolic regulator implicated in tumor stromal-epithelial crosstalk and carcinogenesis49. The gene discussed is HES4; the disease is neoplasm.