The induction of endothelial dysfunction markers ICAM1 (Fig. 9A, trending - P = 0.0782), VCAM1 (Fig. 9B, P = 0.0397) and ET-1 (Fig. 9C, trending – P = 0.2869) by low dose TNFα was more variable than prior experiments, however we confirmed no effect of recombinant CST6 on ICAM1 (Fig. 9A), VCAM1 (Fig. 9B) or ET-1 (Fig. 9C). This evidence concerns the gene EDN1 and endothelial dysfunction.