CST6 and preeclampsia: CST6 protein concentration was significantly increased in plasma obtained from 35 pregnancies complicated by early-onset preeclampsia at a median of 3.50 × 104 pg/mL (IQR, 2.55 × 104 pg/mL – 6.05 × 104 pg/mL) compared to 27 gestation-matched controls at a median of 2.74 × 104 pg/mL (IQR, 1.72 × 104 pg/mL – 1.21 × 105 pg/mL) (Fig. 2A, P = 0.0108).