IL1B and infection: The NLRP3 inflammasome then facilitates the dimerization and activation of caspase-1, leading to the cleavage of pro-IL-1β, pro-IL-18, and GSDMD into their active forms.110 IL-1β facilitates the recruitment of neutrophils and T cells to the site of infection, resulting in the release of secondary wave cytokines such as IL-6 and TNF by epithelial and endothelial cells.