HLA-G and Sepsis: Blood purification therapies have been employed in the treatment of cytokine-associated diseases, with the β2 microglobulin adsorption column being a prominent method investigated for hypercytokinemia resulting from various causes.551 Animal studies have demonstrated a significant decrease in IL-6 and TNF levels in mice with sepsis following treatment with the β2 microglobulin adsorption column.