Consequently, the diverse effects of IL-6 contribute to the development of tissue hypoxia, hypotension, myocardial dysfunction, DIC, and multiorgan dysfunction, all of which are hallmark features of SIRS and septic shock.216 The CS resulting from the significant release of IL-1 and TNF has the potential to induce myocardial suppression, vasodilation, tissue injury, and mortality through the upregulation of nitric oxide synthesis, myocardial cell contraction, facilitation of immune cell adhesion and activation, and initiation of exogenous coagulation pathways.407. Here, TNF is linked to systemic inflammatory response syndrome.