One good example is the treatment for HLH, in which CS signaling is targeted in various ways.553 The treatment of HLH basically comprises two phases: controlling overwhelmed CS with chemotherapy to eliminate activated T cells and inhibit inflammatory cytokine production, and subsequently replacing the defective immune system by allo-HSCT.554 Additionally, IFN-γ antibody (emapalumab) is also applied for HLH treatment. The gene discussed is IFNG; the disease is hemophagocytic syndrome.