IL15 and neoplasm: Additionally, NK cells release chemokines such as MIP-1α, MIP-1β, CCL5, lymphotoxin, and IL-8 to attract myeloid cells and effector lymphocytes to the inflamed tissues.145 The cytokines IL-2 and IL-15 play crucial roles in activating NK cells, with recombinant IL-15 expanding NK cell populations and promoting tumor regression while reducing metastasis.146,147