In an in vivo acute infection model (Fig. 1A), naïve CD8+ T cells from WT (Ftofl/flCD4-Cre−OT-1+, CD45.1+) and FTO KO (Ftofl/flCD4-Cre+OT-1+, CD45.2+) mice were transferred separately into the WT recipient mice (CD45.1+CD45.2+) followed by infection with Listeria monocytogenes (LM) expressing OVA (LM-OVA). The gene discussed is CD8A; the disease is infection.