ASPH and breast neoplasm: Among the four overlapping genes, Gpr65 is predominantly expressed in T cells32, Nrros is linked to the development of neurological diseases33,34, Asph is associated with the proliferation, invasion, and metastasis of breast tumor cells35, and IL-27 is produced by macrophages, and its receptor IL-27Ra was observed on the surface of CD8+ T cells36.