ANXA2 and cancer: High ANXA2 expression is associated with DNA repair in a variety of cancer cells [91], and the Tyr-23 phosphorylation of ANXA2 plays an important role in cancer drug resistance [37], whereas the phosphorylation of ANXA2 Tyr-23 is closely related to nuclear localization, which implies that ANXA2 is likely a potential transcription factor for DNA repair-associated proteins.