ANXA2 and breast carcinoma: Similarly, RACK1 acts as a scaffolding protein that mediates Src kinase phosphorylation of ANXA2 Tyr-23 (pY23), which is associated with various malignant phenotypes, including invasion, metastasis, and EMT, in drug-resistant breast cancer cells [37, 38], and consequently, we speculate that ANXA2 Tyr-23 phosphorylation promotes pY23-ANXA2 nuclear translocation, which regulates the transcription of a variety of tumour-associated factors.