ANXA2 and neoplasm: Furthermore, in tumour cells, ANXA2 is correlated with prognosis and the hypoxic microenvironment [28], and the hypoxic tumour microenvironment upregulates the expression of a circRNA (circADAMTS6) through expression of the transcription factors activator protein-1 (AP-1) and TAR DNA binding protein 43 (TDP43); subsequently, circADAMTS6 recruits and stabilizes ANXA2 in a proteasome-dependent manner [29], which maintains stable ANXA2 expression levels.