The miR-146a rs2910164-rs57095329 and miR-146a rs57095329-IRAK-1 rs3027898 interactions were protective, whereas miR-146a rs2910164-IRAK-1 rs3027898 and IRAK-1 rs3027898-miR-155 rs767649 were significantly associated with an increased MS risk in females. Here, IRAK1 is linked to myeloid sarcoma.