Testing haplotype associations with MS risk revealed that the CCAAA haplotype (alleles in the order of GAS5 rs2067079, miR-146a rs2910164, rs57095329, IRAK-1 rs3027898, and miR-155 rs767649) conferred protection against MS risk compared to controls (CCAAA vs. CGAAT, adjusted OR = 0.14, 95% CI = 0.03–0.69, P = 0.009) after adjustment for demographic variables. Here, IRAK1 is linked to myeloid sarcoma.