Functionally, rs2067079 exerts a trans-eQTL effect on PRDX6. Elevated PRDX6 expression in astrocytes of EAE mice and MS patients has been shown to mitigate blood–brain barrier disruption and neuroinflammation [64]. miR-146a has been implicated in neuroinflammation [65, 66]. The gene discussed is PRDX6; the disease is myeloid sarcoma.