Notably, MS patients with EDSS ≥ 6 had a higher frequency of the minor homozygous CC genotype of IRAK-1 rs3027898 (CC vs. AA + AC, adjusted OR (95% CI) = 4.53 (1.68–12.22), P = 0.0031) and the major homozygous AA genotype of miR-155 rs767649 (AA vs. TT + AT, adjusted OR = 4.35 (1.35–14.06), P = 0.016). Here, IRAK1 is linked to myeloid sarcoma.