Otherwise healthy people with high BMI have also been shown to have increased levels of inflammatory parameters.12 13 An association between high BMI and elevated CRP and/or ESR has also been found in patients with established RA, especially women.13 19 40Adipocytes produce adipokines and proinflammatory cytokines and can thereby lead to a chronic low-grade inflammation, not confined only to the adipose tissue.41 The gene discussed is CRP; the disease is rheumatoid arthritis.