CRP and obesity due to melanocortin 4 receptor deficiency: Among patients with overweight and obesity, there was an increased risk of having a systemic inflammation at follow-up, as assessed by CRP and ESR, which was significant at 3 months of follow-up for CRP elevation (>10 mg/L) and ESR (>20 mm/hour in women and >15 mm/hour in men) compared with patients with normal weight.