Burden-type association analysis (see material and methods) confirmed that, on average, AlphaMissense ≥ 0.75 (odds ratio [OR] = 4.69), ΔΔGAF ≥ 2.5 kcal/mol (OR = 4.35), ΔΔGPDB ≥ 2.5 kcal/mol (OR = 3.62), and BayesDel ≥ 0.28 (OR = 3.59) each identify BRCA1 missense variants with clinically actionable BC risk levels.30 Here, BRCA1 is linked to breast cancer.