The potential role of cellular adaptive immunity in PSP is highlighted by evidence of higher lymphocytes in cases of FTLD-tau.12 That report found elevated CD4 cells but not CD8 cells in FTLD brains, and correlation of CD8 cells with p-tau; however, they evaluated frontal cortex, which is typically not the earliest affected region.1 We found CD8 cells in close proximity to surviving neurons in four PSP brains. Here, CD4 is linked to supranuclear palsy, progressive, 1.